UE
Organic and Inorganic Chemistry
Description
- Revision of aromatic chemistry and the aldol reaction and a comparison of the condensation chemistry of carbonyl compounds
- Imines-enamines - synthesis of heteroaromatic molecules, including pyrroles, furans, thiophenes, pyridines, quinolines and quinolones, indoles, thiazoles, isoxazoles, pyrazoles and pyrimidines
- Reactivity of heteroaromatic molecules towards electrophiles and nucleophiles and comparison of the basicity of pyrroles, pyridines and other nitrogen-containing heterocycles
- The regiochemistry of substitution reactions and the effect of other functional groups on regiochemistry for a number of heteroaromatic systems including pyrroles, furans, indoles, pyridines and quinolines
- Functionalization and metallation at ring positions and substituents; Synthetic approaches towards more complex heterocyclic systems, including alkaloids, fused heterocycles and heterocyclic chemotherapeutic agents.
Compétences visées
The student will be able to: identify the fundamental classes of heterocycles and be aware of methods for the synthesis and derivatization of each;