Organic and Inorganic Chemistry

Description

• Revision of aromatic chemistry and the aldol reaction and a comparison of the condensation chemistry of carbonyl compounds
• Imines-enamines - synthesis of heteroaromatic molecules, including pyrroles, furans, thiophenes, pyridines, quinolines and quinolones, indoles, thiazoles, isoxazoles, pyrazoles and pyrimidines
• Reactivity of heteroaromatic molecules towards electrophiles and nucleophiles and comparison of the basicity of pyrroles, pyridines and other nitrogen-containing heterocycles
• The regiochemistry of substitution reactions and the effect of other functional groups on regiochemistry for a number of heteroaromatic systems including pyrroles, furans, indoles, pyridines and quinolines
• Functionalization and metallation at ring positions and substituents; Synthetic approaches towards more complex heterocyclic systems, including alkaloids, fused heterocycles and heterocyclic chemotherapeutic agents.
   

Compétences visées

The student will be able to: identify the fundamental classes of heterocycles and be aware of methods for the synthesis and derivatization of each;

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