Bioinorganic chemistry

Description

Providing basic understanding of the chemistry of d-block metals in metalloproteins and of metal-based bioactive compounds.

• Role of metal ions in biology, essential and non-essential metals.
• Methods and concepts of importance in bioinorganic chemistry.
• Cu-proteins, Cu-enzymes and their models: electron transfer, activation of oxygen and other moelcuels, oxygen transport, etc.
• Zn in bioinorganic chemistry: Zn-enzymes, structural Zn-sites and Zn as messenger.
• Transport, cell-uptake and storage of iron. Regulators of iron in a cell.
• Metals and health: metal related disease and metal-based drugs

Compétences visées

• Knowing, applying and recognizing the basic principles of (bio)inorganic chemistry in/to different biological and medicinal relevant systems (metal-biomolecules, bioactive metal-complexes, etc.), including systems not treated in the teaching unit.
• Capable of understanding basic bioinorganic chemical experiments and be able to suggest potential experiments to solve a metal-related biological relevant question.

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