EC
Asymmetric Synthesis and Retrosynthesis
Description
The aim is to provide the highest possible level in organic synthesis, and especially in asymmetric synthesis, so that the students can get a job in pharmaceutical and related companies or pursue an academic carrier in organic synthesis.
The stereo- & enantiocontroled construction of molecules - asymmetric synthesis - has becomen a key part of organic synthesis. The bases of asymmetric synthesis will thus be first provided and then exemplified through various enantioselective total syntheses.
Strategy and retrosynthesis is also a key part of this class. Retrosynthesis rules will first be examined and illustrated, and then applied to selected examples of natural product targets.
Organic Synthesis: context & perspectives
- History, roles, applications
- Chirality, complexity
- Planification, Protecting groups
Asymmetric Synthesis
- Principes
- Enantiomer separations
- Chirons
- Prochiral substrates
- Chiral auxiliaries
- Chiral reagents
- Asymmetric Catalysis
- Organocatalysis
Total Syntheses
- Analysis & retrosynthesis
- Compared strategies
Compétences visées
- Analyze & understand scientific publications
- Develop rigorous scientific arguments
- Solve complex problem through reasoning and successive approximations
- Apply reactivity models
- Validate or not models according to experimental results
- Capacity to appreciate the limit(s) of a model
- Design the synthesis of (asymmetric) organic molecules