Radiochemistry molecular probes for in vivo imaging

Description

Introduction to molecular imaging (Positron Emission Tomography (PET) / Single Photon Emission Tomography (SPET));
Radioisotope production (cyclotron including target issues, generator);
Basic radiochemistry (radioisotope incorporation, isotopic labeling versus foreign labeling), applications to the labelling of drug-like molecules (low molecular weight) as well as macromolecules;
Biogenic radiotracer synthesis : incorporation of the short-lived radioisotopes 11C, 13N and 15O;
Non-biogenic radiotracer synthesis : the radiohalogens (18F, 76Br, 123I, 124I) and radiometals (64Cu, 68Ga, 89Zr, 99mTc);
Radiotracer design : pharmacological criteria (lipophilicity, non-specific binding, target density, target affinity and selectivity, metabolism issues, labeling position, pharmacokinetics);
Manufacturing of radiopharmaceuticals : production (automation, synthesis process, reagents and kits), quality controls, radioprotection and waste management, radiopharmacy (reglementary issues, pharmacopoeias);
Selected examples of imaging applications of PET / SPET probes (preclinical / clinical).

Compétences visées

Basic knowledge in molecular nuclear imaging; PET / SPET radioisotope properties and production aspects; design of a PET / SPET radiotracer (drug-like molecules (low molecular weight) as well as macromolecules), based on chemical - ease of introduction, choice of the radioisotope - but also pharmacological - notably metabolism issues - criteria; radiochemistry (radiosynthesis pathway and process, including purification, automation and radioprotection issues); quality controls (analytical methods, specifications) and introduction to radiopharmaceutical aspects.

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